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When House discovers that the experimental drug hes been using causes fatal tumors, he decides to attempt to excise them himself. However, he cant complete the surgery and ends up needing Cuddys help. Meanwhile, Thirteens friend from prison (Amy Landecker), a relapsed drug user, arrives at her apartment needing medical care after being stabbed. With her friend unwilling to go to the hospital, Thirteen enlists Chases assistance when the friend loses sensation and movement in her arm. Also, Taub receives some unexpected news that could change his life.